Agricultural research in Ghana has resulted in a number of innovations targeted at increasing the productivity of small agricultural businesses. However, none of these studies has investigated the factors that influence the adoption of technological innovation in Ghanaian agriculture businesses. Hence, this study examine the factors that influence the adoption of technological innovation in Ghanaian agribusinesses. Structural equation modeling was used to examine data collected from 1526 agribusiness employees in Ghana using a convenience sampling technique and a questionnaire survey. The findings indicate that internal, and external factors have an impact on information and communication technology (ICT), and new materials and technology (NM & NT), but no or little impact on biotechnology (BT) respectively. Also, the study reveal that human capital factors have a substantial impact on ICT, BT, and NM & NT. Lastly, the findings show that ICT, BT, and NM & NT have a positive and significant impact on technological innovation. The study underscores the need for agribusinesses to focus on internal and human capital factors since they increase employees’ productivity and efficiency.