Climate change is expected to have serious environmental, economic, and social impacts on arid regions such as Tunisia country. This research uses a “bottom-up” approach, which seeks to gain insights from the farmers themselves based on a farm household in the south-east of Tunisia. Econometric analyses and Main Component analysis was conducted in this research. Finally, probit binary models were estimated to determine the factors influencing adaptation strategies. All actions aimed at improving the resilience of agriculture in Tunisia’s arid regions to climate change, emphasize mainly the strategies adopted by farmers in terms of water management, technical choices and the adopted production systems combined with the experience and local know-how. Others Government policies and national adaptation programs should focus on education facilitate farmers’ access to extension, information and specialized training needed.